Ibogaine influences the receptors for two major neurotransmitters, serotonin and dopamine. These neurotransmitters are associated with feeling happy and confident; they are also the major point of influence in the brain for cocaine, crack, and meth. These drugs make a person feel euphoric by causing spikes in serotonin and dopamine. Over time, the receptors adjust to the artificially elevated levels and because less sensitive to these neurotransmitters. These drugs also cause the brain to produce less serotonin and dopamine. This explains why heavy drug users develop a tolerance and eventually cannot feel happy at all without taking drugs.
Several studies with animals have shown that ibogaine increases the amount of serotonin that the brain releases, and blocks the brain from reabsorbing excess serotonin. Taken together, these effects dramatically increase the amount of serotonin available in the brain. Ibogaine does not increase the amount of dopamine released, but it decreases how quickly dopamine receptors expel dopamine. This means that the dopamine receptors fire more frequently. These findings explain why ibogaine provides short-term relief from cocaine addiction. The brain of a cocaine user requires high levels of serotonin and dopamine to feel normal, and ibogaine increases those neurotransmitters. Ibogaine must also reset the neurotransmitters; otherwise, the addiction would return full-force within a few days.
Taken from book Ibogaine Explained – Peter Frank . ( www.amazon.com/Ibogaine-Explained-Peter-Frank/dp/1484087372 )